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The drug "Indole" and monthly: the basic principles of interaction 1

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For many years, unsuccessfully struggling with the dairy?

The head of the Institute: “You will be amazed how easy it is to cure a thrush by taking each day.

Vaginal candidiasis is a common disease that many women of reproductive age suffer from. This is due to the fact that the causative agent of the disease (a microscopic fungus of the genus Candida) is part of the natural microflora of the vagina. Due to the effect of predisposing factors on the body, pronounced discomfort appears. Candiston spray from thrush helps to quickly eliminate the symptoms of the disease.

Candidiasis and the reasons for its development

For the treatment of thrush, our readers successfully use Candiston. Seeing the popularity of this tool, we decided to offer it to your attention.
Read more here ...

The vaginal form of candidiasis has a tendency to chronic course, so the disease is quite difficult to treat in advanced cases. Many antifungal remedies for thrush are ineffective or only provide relief for a short time.

Symptoms of the disease appear with the weakening of the body's defenses and lack of intimate hygiene. Among predisposing factors, antibiotics, allergic predisposition and frequent changes of sexual partners should be highlighted. Changes in hormonal levels, for example during pregnancy, is also the cause of the development of the disease.

Any of the above reasons contributes to the uncontrolled reproduction of the fungus, which leads to vaginal candidiasis. This is accompanied by the following clinical manifestations:

  1. The appearance of cheesy vaginal discharge.
  2. The presence of characteristic itching and burning during urination.
  3. Redness and swelling of the mucous membrane of the external genital organs.

The sooner treatment measures are taken, the greater the chance of a speedy recovery. If you do not see a doctor in case of primary symptoms, serious complications such as infection of the urogenital system, progression of endometritis, salpingitis or adnexitis may occur.

Description of Spray Candiston from thrush

A new drug Spray Candiston - an effective and safe antimycotic agent of local action. It was developed on the basis of active bio-elements that have a detrimental effect on the Candida fungus, stopping its further growth.

Antifungal spray strengthens local immunity, which prevents the recurrence of the disease. He passed a series of clinical trials that confirmed a high level of therapeutic efficacy.

Due to the fact that the composition of natural products contain only natural substances, it does not adversely affect the body. Adverse reactions are possible only in the presence of individual intolerance to the components.

Composition and medicinal properties of Candiston

Native substances, on the basis of which Candiston spray was created, possess synergistic properties, i.e. some components increase the effectiveness of others:

  • Anthraquinone Aloe Vera (Aloe Emodin). Restores local immunity and inhibits the growth of yeast microflora. It has a pronounced anti-herpes effect.
  • Glycoside Aloe Vera (Aloe Saponin). It has antifungal and antibacterial effects. Eliminates the likelihood of recurrence of vaginal candidiasis.
  • Thyme and Oregano (L-Thymol). It affects the pathogen by disrupting the membrane structure of conditionally pathogenic microorganisms. The bio-component is active not only against yeast, but also against viruses and bacteria that have a high level of drug resistance.
  • Coconut (Caprylic Acid). Complex carbohydrate also contributes to the dissolution of the membrane of the fungus, localized on the external and internal mucous membranes of the genital organs.
  • Jerusalem artichoke (Inulin). It has anti-inflammatory and anti-mycotic effects, destroying pathogenic flora and relieving symptoms.

Active substances not only destroy the yeast, but also accelerate the processes of regeneration, eliminating the likelihood of developing mycosis.

How to use spray Candiston

For the treatment of thrush can use a natural remedy at home. Instructions for use spray contains recommendations for treatment.

Therapy of vaginal candidiasis should be carried out step by step:

  1. Rinse the genitals with warm water and dry thoroughly with a towel.
  2. Spray the spray on the areas of the mucous membrane and skin that are affected by candidiasis.
  3. Wear clean underwear without using sanitary pads, which are an excellent breeding ground for the fungus.

Repeat treatment should be 3 times a day. If you follow the recommendations on the use of the drug, you can get rid of unpleasant symptoms after the first use of a natural remedy. Although relief has come, treatment should be completed. Otherwise, relapses will not take long to wait.

Advantages of Spray Candiston

The drug does not contain GMOs and is hypoallergenic. With the help of the spray, you can restore the natural microflora of the vagina, strengthen local immunity. This helps to stimulate the protective functions of the body, independently suppressing the activity of opportunistic microorganisms.

Every woman who used Candiston noted the following benefits:

  • The destruction of fungal infections and the absence of addiction.
  • Reducing the intensity of symptoms after initial use.
  • Rapid healing of microtraumas and ulcers on the mucous membrane of the genital organs.
  • No adverse reactions and discomfort even after prolonged use.
  • Sufficient efficacy even in the treatment of chronic forms of vaginal candidiasis.
  • Preventing the development of complications and getting rid of thrush in one course of administration.

As for the price, many people think that Candiston, whose price is about 900 rubles, is expensive compared to other pharmacological preparations for thrush. But, given the natural origin of the components and the effectiveness of the spray, this price is more than justified.

Where can one buy

Buying Spray Candiston better on the manufacturer's website. The price in pharmacies for the drug is too high, due to the inclusion in the cost of additional costs. Be careful and use only the official source to make a purchase in order to exclude the possibility of acquiring counterfeits.

Drugs that can be bought at the pharmacy are highly effective against thrush, but can cause adverse reactions. In this case, it is imperative to first consult with your doctor. Kandiston spray, developed on the basis of natural components, can be used independently, without a visit to a specialist, since it is absolutely harmless.

What do doctors say about the drug?

What they say about spray Candiston reviews of doctors. They mostly confirm the effectiveness of the drug. Muravleva A.S. (obstetrician-gynecologist), who has been working in the specialty for 15 years, recommends her natural patients to use this natural spray.

The spray has a complex therapeutic effect, destroying pathogens and restoring local immunity. Mycotic infection dries out right before your eyes. In practice, cases of successful relief from the chronic form of vaginal candidiasis were recorded.

Customer Reviews

Candiston's price is justified, since one bottle of spray is enough for complete recovery. No need to buy expensive vaginal suppositories and swallow capsules dangerous to health. It is enough to buy a natural remedy and complete a full course of treatment.

The real customer reviews about spray Candiston:

Snezhana (27 years old, Saratov)

I bought Candiston spray at an online pharmacy during pregnancy, when I started to have thrush. I did not drink pills, but decided to try a natural remedy. Painful symptoms and swelling gone away after 2 days. Just an incredible effect!

Vera (47 years old, Ufa)

I suffered serious hormonal changes that affected immunity. Signs of candidiasis did not disappear even after treatment with suppositories under the supervision of a physician. Bought on the internet Candiston. Regular spray helped to recover in 2 weeks!

Julia (32 years old, St. Petersburg)

Saw antibiotics, and for the preparations of thrush I regretted the money. After that, she suffered from chronic candidiasis. A friend, having learned about my problem, advised Spray Candiston. I did not immediately believe that he would help. For half a year I have been living a normal life, without even remembering the past discomfort.

Conclusion

Spray Candiston - an effective drug for thrush, developed on the basis of natural ingredients. The drug relieves the symptoms of thrush after 2-3 hours, continuing to fight the causes of the disease. In order to achieve the result of treatment declared by the manufacturer, it is necessary to follow the recommendations for use set forth in the instructions for use.

The drug "Indole" and monthly: the basic principles of interaction 1

Many women prefer different herbal remedies and dietary supplements as a treatment, considering that they are harmless, and the result is “on the face”. Indole forte is one of the most popular drugs, the main active ingredient in which is indole-3-carbinol. It has a multifaceted effect, including anti-estrogenic, antitumor. How does the substance work and in which preparations can it be found? Is it true that taking indole and menstruation is normalized, and mastopathy passes?

Application in gynecology

Indole Forte is a natural product from the group of dietary supplements, the main action of which is aimed at normalizing the reproductive function of a woman and the functioning of the genital organs, as well as their interrelated structures.

The structure includes the following components:

  • Indole-3-carbinol, which is obtained from cruciferous plants. These include cabbage, rutabaga, turnip, radish and others.
  • Broccoli extract. The fact is that this particular vegetable is the record for the content of indole-3-carbinol. Thus, the drug contains the maximum possible concentration of the active substance.

By consuming just one capsule daily, the woman completely satisfies the body's needs for indole-3-carbinol.

Indole Forte is recommended to be taken for the following gynecological diseases:

  • Violation of the menstrual cycle caused by hyperestrogenemia and lack of gestagens in the body. The fact is that indole-3 carbinol blocks the enzymes that are actively involved in the formation of estrogen. It also increases the amount of proteins in the blood that bind female sex hormones. Equally important is the fact that indole-3-carbinol competes for estrogen receptors. As a result, their level decreases and their monthly periods gradually normalize.
  • Indol forte is also effective in the treatment of mastopathy. As you know, the main cause of this benign disease is an imbalance of sex hormones. A regular use of the drug helps to normalize the ratio. Also indole-3-carbinol contributes to the destruction of all abnormal cells, thus providing an antitumor effect, for example, in fibroadenomas. The drug reduces the rate of growth and formation of blood vessels in pathological foci. And in conditions of lack of oxygen and nutrients there is a gradual decrease in seals.
  • This effect of Indole Forte favors slower growth and even a decrease in the size of uterine fibroids.
  • On the background of the reception gradually decreases the appearance of endometriosis.
  • Indole-3-carbinol is involved in the body’s antioxidant system. Due to this, it is effective to use the drug in the complex treatment of cervical dysplasia, genital condylomatosis and various hyperplastic processes in the uterine cavity.
  • Recommended for use in breast cancer and cervix. In the latter case, its therapeutic effect is due to inhibition of reproduction and activity of the human papillomavirus. It is known that it plays a significant role in the development of cervical cancer.

As you can see, the range of use of the drug is quite wide. However, it should be emphasized once again that, as the only treatment, Indole Forte is much less effective than in combination with other medications whose action it complements and potentiates.

Indole Forte can be used in the presence of the disease, and for the prevention of disorders and the development of pathological conditions in the presence of provoking factors.

See the video on the use of the drug:

Possible side effects and contraindications

As with any drug, on the indole forte may develop an allergic reaction. Especially it is necessary to be careful of women with hypersensitivity to cruciferous plants. It is better to apply alternative methods of treatment in such cases.

At the time of using Indole Forte, it is better to exclude from the use of drugs that affect the acidity of gastric juice, as this may affect the effectiveness of treatment.

For the treatment of thrush, our readers successfully use Candiston. Seeing the popularity of this tool, we decided to offer it to your attention.
Read more here ...

Can I drink during menstruation

Many women are interested in whether Indol forte is combined with menstruation, or it is necessary to take a break in reception during critical days.

This drug acts as a biologically active food supplement, so you can take it at any time, regardless of the day of the menstrual cycle: at the beginning, in the middle or during bleeding. But manufacturers still recommend starting reception from the first day of menstruation.

It is also completely authorized to use the product together with oral contraceptives. Indole Forte will help the body maintain ovarian function at a minimal, threshold level. Thanks to this, after the abolition of oral contraceptives, their work is restored faster.

Indole forte is presented in pill form for ingestion; vaginal forms do not exist.

Influence on a cycle and profusion of monthly

Regular courses of indole forte contribute to the normalization of the hormonal background of women, adjust the sensitivity of its tissues to estrogen. All this leads to the restoration of the normal cycle of menstruation. The painfulness, the spotting on the eve of critical days, as well as the degree of manifestation of premenstrual syndrome decrease.

Hyperestrogenesis contributes to the development of endometrial pathology and the appearance of uterine fibroids, which entails abundant menses. Indole forte is able to reduce to some extent the manifestations of the disease, leading to the amount of blood lost to normal.

Can Indole Forte cause a delay in menstruation? By itself, the drug can hardly affect the menstrual cycle. But its use may coincide with violations, especially if a woman and before that there were various failures. And in such situations, the girl may associate the use of the drug and the menstrual cycle.

There are several drugs on the market that are analogues of Indole Forte.

The most popular are:

In addition to indole-3-carbinol, soybean and green tea extract are included. Each of the compounds is a source of phytoestrogens for women. Used tool for the prevention and treatment of gynecological diseases, including benign and malignant tumors.

The package contains tablets of three colors: yellow, green and red. They must be taken during breakfast, lunch and dinner, respectively. The manufacturer recommends three-month courses every six months. If necessary, therapy may be extended.

In addition to indole-3-carbinol, the following components are included:

  • extract of tsimitsifuga, root of wild yam, soybean, vitex,
  • boron, vitamins B6, E, folic acid,
  • Amino acids based on tryptophan and phenylalanine.

This complex is effective for the treatment and prevention of menopausal disorders. In particular, with regular use decreases the frequency and severity of hot flashes, heartbeat episodes, elevated blood pressure, increased sweating. Psycho-emotional state of a woman is normalized, mood swings and attacks of aggression and irritability, which often arise as manifestations of menopausal disorders, are smoothed out.

Estrovel is recommended for use after removal of the ovaries for the prevention of post-attrition syndrome, as a treatment and prevention of menopausal disorders, as well as for the correction of premenstrual syndrome.

In addition to the main action, the antitumor activity of the drug due to indole-3-carbinol and the ability to normalize hormonal levels are preserved.

Рекомендуем прочитать статью о препарате «Эстровэл«. Из нее вы узнаете о составе и действии препарата, показаниях и противопоказаниях к его назначению, а также эффективности при купировании климактерического синдрома.

Данный препарат также относится к числу БАДов, содержит только индинол-3-карбинол 100 мг в своем составе. Принимать рекомендуется средство курсами по 3 — 6 месяцев, выпивая при этом по две таблетки дважды в сутки.

Индол плюс

Содержит, помимо индол-3-карбинола, экстракт из следующих продуктов:

  • плодов и проростков брокколи,
  • листьев артишока.

Именно в этих растениях содержатся природные резервы индол-3-карбинола, благодаря их наличию действенность препарата многократно увеличена.

In addition to the prevention and treatment of various gynecological diseases, it can be used to normalize all functions of the body, for its detoxification. This drug can improve the work of the digestive system and the liver in the neutralization and elimination of metabolic products. It also improves the functioning of the antioxidant system, providing a healing, rejuvenating and antitumor effect.

All these properties are due to the rich mineral, vitamin composition of extracts.

Indole plus need one or two capsules only once a day for 1 to 2 months.

Indole Forte is a dietary supplement that can, when used regularly, protects against many female diseases. It has anti-tumor properties, normalizes the level of sex hormones in women. There are several drugs-analogues, which in addition contain vitamins, microelements and extracts of other plants. By this they expand the profile of their impact. However, even its use is advisable to coordinate with your doctor, who will confirm the safety of use in a particular situation.

General characteristics of drugs used from thrush

Drugs that allow men to get rid of intestinal thrush, as well as the vaginal form of the disease for women, including during pregnancy, are now on the pharmaceutical market in large quantities. Information on each of them is available both on the Internet and directly on the package insert. All anti-candidal drugs (drugs to combat thrush) can be divided into several groups.

We offer you a small list:

  • Antibiotics of the group of polyenes, which include drugs such as "Natamycin" and "Nystatin."
  • Derivatives from triazoles, for example, Fluconazole.
  • Derivatives of active imidaloldioxalan. The representative is Livarol.
  • The group of imidazole derivatives, the most well-known and effective among which is "Clotrimazole".

But, nevertheless, taking drugs purely for their own reasons will not bring positive results, since the process of self-treatment may aggravate the situation, bringing the disease to a chronic state.

It is especially dangerous to engage in self-therapy during pregnancy, because it can be harmful not only for the expectant mother, but also for the baby.

Unlike acute candidiasis of the intestine or vagina, when only local drugs are allowed, in chronic or frequently repeated forms, this type of treatment together with oral medications becomes simply necessary. This results from the fact that only local treatment does not give a full recovery. A special case is candidiasis during pregnancy, which should be treated with antifungal agents under the supervision of a doctor. What exactly is suitable for pregnant women against this disease, determines the attending doctor.

Clotrimazole

Testimonial from patient Ekaterina, 33 years old

Very good for use by those who suffer from recurrent or persistent form of thrush, where conventional drugs are not sufficiently strong. I had precisely continuous recurrent form. What can I say about this drug:

Composition - creamy. The color is white and the density is medium. Almost no smell. When applied to the mucous does not spread much and very quickly absorbed. It will not be superfluous to use personal hygiene to hide the leaking excess cream, namely, daily. In addition, the instructions say that this medicine is suitable for the treatment of thrush in men. Not recommended for women during pregnancy.

For myself, I noted the benefits of this medication:

  1. convenient to use
  2. effective as a medicine in common forms and in combination with complex forms of the disease,
  3. effective in many other diseases of the fungal and lichen type,
  4. can be found in almost any pharmacy in the country
  5. low price (when I bought, cost 30 rubles).

I do not like other vaginal forms of drugs, so I use only ointment. But with the chronic form of the disease, I also took pills because often there is not enough local therapy.

Testimonial from Anna, 40 years old

The drug "Nystatin" - this is my first aid to fight against thrush. These low-cost suppositories for direct intestines are both very small and convenient to use (so men may not be afraid). A pill - a real find, they are especially convenient for use.

But once I somehow lost sight of them. Oh, and I was tormented then! One winter, I had an acute attack of cystitis in combination with intestinal candidiasis, the pains were terrible. Everything that did, they did not remove, endlessly ran to the toilet, and the intestines squeezed spasm. And I decided to resort to a hot bath: I typed it, climbed up and sat for about a couple of hours. Finally, the long-awaited relief. And the next day I was waiting for a new unpleasant surprise - vaginal candidiasis (I think many women will understand me) that they wanted to climb on the wall. Then the cystitis reminded me again, and the intestinal spasms returned. Such a funny set, only the one who has experienced it will understand me.

And if I cured cystitis with Cystone, then thrush of the intestine and vagina tormented me for a long time later. I tried different medicines for thrush and in different forms (suppositories, pills), and she returned. To doctors did not apply. And then I remembered "Nystatin." These affordable suppositories and pills were my salvation! I quickly ran to the pharmacy and started treatment on the same day. The cost of one package of candles was 40 rubles (10 pieces).

Dear women and men, I advise you only "Nystatin"! Checked by my long-suffering experience. And even better - contact the doctor (even for many men this is a delicate question).

Opinion of the patient Irina, 23 years

Once I had to take antibiotics for a long time and, as a result, I very quickly ran into a thrush. If at that moment the pharmacist at the pharmacy did not advise me "Nystatin", I would itch to death from her. This itch is difficult to survive! But the drug helped instantly! Now, if I take antibiotics again, then only always with him for prevention. There were no side problems at all, cheap and effective. Indispensable in the first aid kit!

Fluconazole

Review from Tatiana's patient, 37 years old

I want to express my opinion on modern expensive medicines - this is “Diflucan” and “Flucostat” for 500 rubles. - and their cheap counterpart Fluconazole for less than 40 rubles. To be honest, this is not just a similar drug, its active ingredient is the same. I very much want many, many ordinary citizens to read about my impression and no longer allow themselves to be so brazenly deceiving themselves.

There is such a thing - generic drugs, that is, similar to expensive, but at the same time much, much more affordable. They have one to one active active ingredients, but their price is several times less. However, Fluconazole cannot be used by women during pregnancy. I’ll personally say about efficiency: he is very good. I took only one pill and got a quick, visible, personally tangible result on the very first day. And all this despite the fact that the cost is not 10 times lower, but even cheaper (600 rubles versus 30 rubles). And the difference in 570 rubles is impressive, isn't it?

Review from Tatiana's patient, 34 years old

I can safely consider myself a “candidate of sciences for the war with candidiasis,” including during pregnancy. And I know from my own experience that no miracle pill can cure against everything. An integral part of treatment is always topical medication.

I used a lot of antifungal agents in my difficult struggle - candles and tablets of the widest range of cost.

And only “Livarol” cured me in the last trimester of pregnancy, and did not cover the symptoms for a while. What is the point of treatment at the time? So, the reason remains, and the money is spent in vain. And the patience is also not rubber!

What you need to know about the candles "Livarol"? I will summarize the following:

  • White suppositories. Size - medium.
  • There are packs of five and ten. It is better to take the latter, so as not to miss.
  • The cost at the time when I bought - about 450 rubles. for 10 pcs.
  • When used and after the course, there was no discomfort at all (but this is not the case with all pregnant women, so be careful and consult a doctor).
  • Full recovery even in a neglected case (as it was with me) - on day 9.

I know that many people give candles against Candidiasis “Clotrimazole” as opposed to “Livarola”. Like, they are cheaper. Do not believe. I tried this remedy and got terrible irritation in addition to the itching and discomfort that already happened. Here Clotrimazole ointment seems to be nothing, but as a whole it has little effect against this disease. Can be used as a supplement, and not as a primary treatment.

Now, when diseases are forced to swallow antibiotics, I definitely begin to use Livarol in candles. Do not neglect and wait, that will carry. My opinion is that you need to be safe. I always have at least five candles in the first-aid kit. As prevention - it is quite enough and very effective! I wish you all a speedy recovery.

Whatever the opinions of medications, remember some important points:

  1. To begin with, contact your doctor if you have problems with the intestines and the genitourinary system.
  2. Men are often shy, and going to the doctor is a necessary measure.
  3. Seek advice is especially important for women during pregnancy, when problems may have a serious outcome. After all, all those signs that you take for candidiasis may be associated with a completely different disease. And if you are treated according to the standard treatment regimen or according to the one that suits someone else, the treatment will not necessarily help you. In some cases, there may even be prerequisites for exacerbating problems - improper development of the fetus during pregnancy, pathology of the prostate gland in men, etc.
  4. In addition, not all drugs that are suitable for men can be recommended for pregnant women, this should be remembered!
  5. Therefore, it is necessary to undergo a good examination by a doctor, and then make a decision on which antifungal agents to be treated, based on his recommendations.

INDOL-3-CARBINOL WITH EXTRACT OF LIGNANS FROM FLAX SEEDS

A unique agent and drug of choice for the prevention and treatment of hormone-dependent tumors (uterine fibroids, endometriosis, mastopathy, cervical dysplasia, prostate adenoma), papillomatosis, as well as to protect the liver from hepatotoxic substances. Powerful oncoprotector.
The content of indole is 200 mg!

Manufacturer: NOW Foods, USA.
Release form: capsules of 60 pcs. in a glass jar.
Composition 1 capsule Indol-3-Carbinol:

  • Indol-3-Karbinol 200 mg
  • Extract of lignans from flax seeds (content of Secoisolariciresinol diglycoside minimum 10 mg) 200 mg

More than 20 years ago, scientists drew attention to the relationship between the high consumption of cruciferous vegetables (various types of cabbage, radishes, turnips, rutabaga) and the incidence of bowel, breast and uterus tumors in women and prostate cancer in men. Peoples, in the diet of which there are a large number of these vegetables, tumor diseases are found several times less. It is believed that in order to obtain a positive effect, it is necessary to consume about 1 kg of these products daily.

In this regard, from plants of the family of crucifers it was possible to isolate substances with antitumor activity: ascorbigen, indole-3-carbinol, etc.

How does Indol-3-Karbinol on the body?
Indol-3-Karbinol is a powerful oncoprotector, because:
• Indol-3-Karbinol changes estrogen metabolism in the liver, reducing the proportion of carcinogenic metabolites, and, conversely, increasing the concentration of oncoprotective fractions,
• Indol-3-Karbinol blocks the biochemical activity of receptors for estrogen in epithelial and tumor cells,
• Indol-3-Karbinol directly blocks the cell cycle of tumor cells,
• Indol-3-Karbinol increases the activity of detoxifying liver enzymes that metabolize hormones, various toxins and carcinogens, helps to neutralize toxins, including those with carcinogenic properties,
• Indol-3-Karbinol provides powerful antioxidant protection, saving cells from damage by free oxygen radicals,
• Indol-3-Karbinol selectively causes the death of cells containing the human papillomatosis oncovirus, promotes apoptosis (death) of cancer cells.

Indications for use of the drug Indol-3-Carbinol:
• prevention and therapy of hormone-dependent tumors - uterine fibroids, endometrial hyperplasia, endometriosis, mastopathy, dysplasias and malignant tumors of the cervix uterus (in complex therapy), prostate adenomas.
• treatment of acute and chronic hepatitis, cirrhosis, chronic alcoholism.
• diseases caused by the human papillomavirus: genital papillomatosis, genital warts, recurrent respiratory papillomatosis, etc.
• osteoporosis.

This product is especially needed for those who:
• there is a need for liver detoxification,
• there is an excess of estrogen,
• low testosterone levels were detected,
• there is a predisposition to the formation of papillomas,
• there is a risk of cancer or those undergoing cancer treatment.

The drug Indol-3-Karbinol is the drug of choice for the prevention and treatment of hormone-dependent tumors, as well as to protect the liver from hepatotoxic substances.

Mode of application:
In order to prevent adults 1 capsule 2 times a day with meals. Reception duration - 2 - 3 months.
When mastopathy, endometriosis, mime uterus, cervical dysplasia, prostate adenoma - 2 capsules 2 times a day for 6 months.
In all forms of human papillomavirus infection, 2 capsules, 2 times a day for 3 months.

Contraindications: individual intolerance to the components that are part of Indol-3-Carbinol. Not recommended for persons taking drugs that lower the acidity of gastric juice, as well as pregnant and lactating women. Before use, consult your doctor.

In the presence of the unique properties of "Indol-3-Karbinol" has no serious side effects, which makes this drug indispensable for long-term use, both for prevention and during treatment.

Storage conditions Indole-3-Karbinol: Store in a cool, dry place.

What is the effect based on?

Indole-3-Karbinol is absorbed in the small intestine as diindolylmethane (DIM), which determines the beneficial properties of this product. DIM selectively binds to estrogen receptors and acts as an estrogen antagonist. At the same time, it helps maintain testosterone levels, preventing the transformation of testosterone into estrogen.

Indol-3-Karbinol prevents the formation of dangerous metabolites in the process of transforming female sex hormones - estrogen. So it blocks the formation of 16-C-hydroxyestrone (estrogen decomposition product), which binds to estrogen-dependent receptors and causes uncontrollable proliferative processes, being a tumor-forming factor in relation to a number of organs: the reproductive organs of not only women (primarily the uterus and mammary glands) but also the reproductive organs of men, the gastrointestinal tract, the pancreas and the thyroid gland.

Another effect of Indol-3-Carbinol is to shift the ratio of metabolites of female sex hormones estrogen in favor of the formation of 2-C-hydroestrone, which leads to inhibition of the development of human papillomatosis virus (HPV) and stops the formation of papillomatous formations that are prone to infiltrative growth and malignancy ( ). Target organs for HPV are the mammary gland, the organs of the anogenital region (the anus region, the vulva, the vagina, the cervix), and the mucosa of the larynx and bronchial tree.

Pay attention to another property of the drug. In addition to indoles, broccoli extract contains isothiocyanates, which, together with indoles, maximally stimulate the processes of detoxification and biotransformation of toxic substances from the body. These substances are able to increase the detoxification function of the liver and the activity of the main protective enzymes dozens of times.

The second component of the drug - lignans.

Flaxseed - one of the richest sources of lignans, which have an anticarcinogenic effect, is an antiallergen, as well as a powerful antioxidant effect. Flax seed coat is the richest plant source of lignans. Lignan is a powerful antioxidant, immunomodulator and phytoestrogen. In addition, the lignans showed such a strong potential as a cancer preventative that they were recommended by the National Cancer Institute (USA and Canada).

Лигнаны в толстом кишечнике в результате микробного метаболизма превращаются в активные фитоэстрогены – энтеролактон и энтеродиол, которые нормализуют гормональный баланс и также защищают репродуктивные органы от развития гормонально зависимого рака. Особенно это очевидно в случае рака молочной железы. Антираковая активность фитоэстрогенов связана с тем, что они:
- подобно лекарственному препарату тамоксифену блокируют альфа-рецепторы на клетках эпителия и раковых клетках от избыточной пролиферации под действием эстрогена,
- блокируют активность фермента ароматазы жировых клеток молочной железы, предупреждая локальное образование высоких концентраций эстрогена,
- стимулируют синтез в печени специальных белков, связывающих половые гормоны в плазме крови, что приводит к снижению концентрации эстрогенов в крови.

In addition, phytoestrogens are antioxidants, have anti-atherogenic and antithrombotic action, prevent age-related bone resorption and the development of osteoporosis.

The effect of indoles and lignans is based on:
- reducing the activity of its own estrogens by translating them into a less active form,
-reduction of estrogen receptor sensitivity,
-increasing the activity of detoxifying liver enzymes, inactivation and elimination from the body,
- directly by blocking the cell cycle of tumor cells

Experimental studies have shown that Indol-3-Carbinol exhibits high antitumor activity, normalizes the metabolism and balance of female sex hormones (estrogens), which contributes to the prevention of the development of tumor processes of the breast, female genital organs, and the prevention of prostate tumors in men.

Indinol and its analogues in the treatment of hormone-dependent tumors

Indinol - This is a herbal preparation derived from cruciferous vegetables (broccoli, kohlrabi, leafy, white, cauliflower, red cabbage, radishes, turnips). Scientists have found that women who consume 900 grams of leafy greens (better than broccoli) daily are protected from the occurrence of cancers of the reproductive organs, especially breast cancer. But few adhere to such recommendations. Therefore, manufacturers of food additives actively fill this gap.

Active ingredient indinola is an Indole-3-carbinol (I3C), which has anti-estrogenic and anti-tumor effects. Indole-3-carbinol can be called a universal remedy that corrects pathological processes in the reproductive organs of both women and men, acting selectively on the processes of destroying tumor cells without affecting healthy ones, normalizes the metabolism of estrogens in the body and prevents the development of estrogen-dependent diseases, accelerates the excretion of potentially harmful substances, including carcinogens. According to research at the University of California at Berkeley, I3C stops the growth of new blood vessels that tumors require for their survival and metastasis, protects the bone marrow during chemotherapy

Doctors prescribe medication with indole-3-carbinol: in case of mastopathy, breast cancer, ovarian cancer, cervical erosion, uterine myoma, cancer of the body and cervix, ovarian cysts, endometriosis, premenstrual syndrome associated with elevated blood levels of estrogen and in diseases caused by human papillomavirus (manifested by warts, papillomas), with prostate adenoma.

Effect of Indol-3-carbinol on estrogen metabolism in women and men

I want to elaborate on the role of Indol-3-carbinol in the metabolism of estrogen, as many mistakenly believe that it affects the amount of estrogen.

Estrogens (these include estradiol, estriol and estrone )Those who perform their functions in the body should leave it after the hydroxylation reaction - transformations into water-soluble metabolites (hydroxyestrogens). After this, they are detoxified and sulphated - the final conclusion of the metabolites with urine or feces.

Enumerate the three major metabolites of estrogen:

  • 2-OHE1 (2-hydroxyestrogens) - "good" metabolites that support the normal functioning of tissues and resist the occurrence of cancer cells.
  • 16-OHE1 (16-hydroxyestrogens) - “bad” metabolites that cause excessive growth of tissue cells, as a result, benign tumors develop: myoma, mastopathy, endometriosis processes, etc.
  • 4-OHE1 (4-hydroxyestrogens) - "dangerous" metabolites that can cause malignant degeneration of tumors, which leads to the development of cancer!

Uterine tissues attract and hold estrogens in their layers, they are like accumulators of this hormone and its metabolites. And with their imbalance with a predominance of carcinogenic women receive oncology. And so indole-3-carbinol reduces the number of "bad" metabolites and increases the number of "good", that is, it simply shifts the ratio of metabolites in favor of the good ones.

All this is true not only for women, estrogens are present in the male body. This is the first. And secondly, indole-3-carbinol has a positive effect on metabolism of male androgen hormones. Testosterone can turn into very active dihydrotestosterone, an excess of which leads to prostatic hypertrophy and hyperplasia, the development of prostate adenoma and the likelihood of developing prostate cancer. Indole-3-carbinol reduces the frequency of conversions of testosterone to dihydrotestosterone. In addition, testosterone can turn into estrogen. Estrogens are very important for men - surprisingly, they are responsible for male libido, including health in general. But the excess of estrogen in men is female obesity, depression, sexual dysfunction, decreased libido. This is especially true for overweight men, since adipose tissue actively synthesizes estrogens from testosterone (by the so-called aromatization) and accumulates them, and indole-3-carbinol prevents undesirable conversion of testosterone to estrogen. The most important consequence of all this is male prostate health. And, according to statistics, prostate adenoma (its growth) by the age of 40-50 is observed in every fourth man, and then the numbers are only growing.

Summarize: Indole-3-carbinol is a powerful anti-tumor and anti-cancer agent.. Excellent proven in the prevention of any tumors and abnormal growths of tissues in the body.

Features of use and dose

Typically, therapeutic dosage is 400 mg per day (taken with food), but if necessary, can be increased to 1200 mg, in which case it is necessary to divide into several doses with a gradual increase in daily dosage. If you notice a heaviness in the stomach, then add enzymes.
The recommended course of treatment is 3-6 months.

For enhance the effectiveness of indole-3-carbinol gynecologists prescribe Russian drug Epigallat. It is based on green tea extract, which has anti-inflammatory and antioxidant effects. I recommend to see the American equivalent from Now Foods, EGCG, Green Tea Extractwhich is enough for the entire six-month course of admission.

And add lecithinas his phospholipids are involved in all hormonal processes and help excrete the decay products of tumor cells: Now Foods, Lecithin, 1200 mg, 400 cap. - soy lecithin for women, sunflower for men - Now Foods, Sunflower Lecithin, 1200 mg, 200 cap.
For the complete elimination of the already processed estrogen and toxins from the liver is needed Calcium D glucorate (calcium salt D-glucuric acid). Without it, excess estrogens will be returned to the system, rather than removed from the body.

Contraindications:
Pregnancy, breastfeeding (in this group, studies were not conducted), individual intolerance to its components. Poor digestion.

Analogs of Indinol: where to buy, price

For comparison, she took a drug called "Indinol forto", which included the optimal amount of the active ingredient of indole-3-carbinol - 200 mg. and its counterpart from the well-known American manufacturer NOW Foods. "Indinol forto" is registered on the territory of the Russian Federation as a medicine, but it is not at all clear what this classification is based on, because the rest of domestic analogues are sold as dietary supplements, apparently due to the addition of preservatives and other harmful substances in the capsule.

Composition:

Active substance: 1 capsule contains 0,200 g indol-carbinol (intrinol).

Other Ingredients: lactose monohydrate (milk sugar) - 0.140 g, modified corn starch - 0.095 g, cellulose - 0.064 g, magnesium stearate - 0.001 g.
Shell composition: gelatin, purified water, titanium dioxide E 171, dye yellow E 110.

Enough for 30 days (at the rate of 1 capsule 2 times a day, 400 mg)
Price in Russia: 3041 rub

Composition:

Active substance: 1 capsule contains 0,200 g Indole-3-carbinol (I3C), 0,200 g LinumLife Complex (Linseed Lignan)

Other Ingredients: rice bran, silicon dioxide and magnesium stearate (vegetable source)

Shell composition: cellulose


Enough for 30 days (at the rate of 1 capsule 2 times a day, 400 mg)
Price in iHerb: $ 16.56 (RUB 1,084 as of 11/18/15)

I can not help but notice that in the American drug from NOW Foods is added LinumLife flaxseed complex, which is a good source of Lignans. What are lignans? These are phytonutrients, which turn into estradiol and enterolactone in the body - forms of estrogen, which are necessary for the female body, primarily for reproductive function.
Moreover, it has been clinically proven that taking lignans reduces hot flashes in women in menopause. And tides, as is known, arise from the lack of “good” forms of estrogen.

Another plus in favor of the American Indol-3-carbinol is an affordable price, 3 times less than the cost of Indinola Forto.

Indole-3-Carbinol Reviews

Before buying, many people are interested in real reviews of how the drug worked, and so there are a lot of them in the network and they range from enthusiastic positive to negative - consider them all. But if your doctor advises you to take the drug, then you should listen. Why are the reviews different? The fact is that the body of each person is unique and for each of us different drugs, be it dietary supplements or drugs, act in completely different ways, even with the same problem.

I will say for myself: Indol-3-carbinol made my life much easier, although the problem did not go away completely (still in the course of treatment), I take the drug easily. I will continue to order.

And for those who have stomach problems, drugs with I3C will be hard tolerated and will not give the desired results. In this case, I recommend to consider DIM based drugs, they are more expensive, but also effectively neutralize carcinogenic metabolites without gravity to the stomach.

Main characteristics of Indole

The medicinal substance is obtained by processing certain fruits and herbs belonging to the cruciferous family of plants. Biologists and biochemists emphasize that most of the gifts of the nature of this type of flora have a strong anti-cancer effect. A pronounced representative of such plants is, for example, ordinary cabbage.

In medical practice, several useful qualities of Indole are used at once:

  • First of all, a medicine made from raw materials obtained from the queen of vegetable gardens affects the level of influence of female sex hormones-estrogens on the tissues of the mammary glands, reducing the likelihood of rebirth of benign processes in cancer of the female breast.
  • Many experts note the effect of this substance on the liver cells, where they interrupt the restructuring of most of the precancerous cells into carcinogens.
  • Indole is an excellent antioxidant and, thanks to this property, takes an active part in the removal of waste products from the tissues and cells of the female body.
  • No less important is the effect of a biological additive on the production of glutathione, a natural antioxidant that stimulates metabolic processes in tissues at the cellular level.

Therefore, in the treatment of mastopathy, this substance is used exclusively as a measure to prevent the transition of the benign process in the patient's mammary glands to the malignant process.

We recommend to read an article about the drug Stella with mastopathy. From it you will learn about the effect of the drug, indications for use, as well as whether it is possible to use dietary supplements for mastopathy.

And here more about the prevention of mastopathy.

Indications for use of Indola tablets

Despite the fact that the considered biological additive is not a medicine in the usual sense for doctors and patients, experts clearly outlined a range of problems for women, for whom it is recommended to prescribe Indol:

  • Doctors recommend this remedy for a fortifying effect on the patient's body, as a substance that has a beneficial effect on her immune system.
  • In medicine, Indol is widely used as an antioxidant: the drug helps slow down the aging process of cells and at the same time is used as a sorbent, as it perfectly cleanses tissues from various toxic substances.
  • This dietary supplement is widely used in gynecology as a drug, stopping most of the symptoms of PMS, including severe pain during menstruation.
  • Given the effect on estrogen in the female body, it is successfully used to stabilize various hormonal disorders in women. This includes both the consequences of various diseases, and the failure of the hormonal balance in a woman, due to pregnancy and childbirth.

Most doctors agree that the main function of Indole is the fight against cancer in the fair sex. That is why this herbal remedy is widely used in various benign diseases of the female genital organs, especially the mammary glands.

Look at the video about mastopathy:

Side effects and contraindications to taking pills

Like most other biologically active substances, the drug under consideration does not have an extensive range of contraindications. It is advised to administer it with caution if the patient has the following problems:

  • Chronic diseases of the gastrointestinal tract, especially of the liver and pancreas. Some authors have noted the likelihood of the effect of Indole on the formation of gallstones.
  • Scientists are still arguing about the effects of this drug on the child’s body. Therefore, its use until the patient is 18 years old is not recommended.
  • When using biologically active substances, allergic reactions are quite rare, however, various pathological manifestations cannot be completely ruled out in patients. Most often it is a different rash, redness of the skin, fever, weakness, nausea and vomiting.
  • The use of this medication is completely prohibited during pregnancy and during breastfeeding.

The drug is not an independent medicine for mastopathy and other diseases of the female genital organs. Dietary supplement is used exclusively as an enhancement agent in combination with radiation therapy, chemotherapy, after surgery.

Indole is considered an excellent means to restore hormonal balance, especially the percentage of estrogen in various benign and malignant processes in the mammary glands, cervix and appendages. Side effects in women most often occur as a result of the primary treatment, and not the use of Indole.

How to take indol with mastopathy

In the pharmacy network, this dietary supplement is most often represented by the drug Indol-3-carbinol, which is made on the basis of processed broccoli cabbage flowers. One bottle contains 60 capsules coated with a special gelatin sheath. Such a precaution helps the drug to enter the patient's intestine, avoiding the decomposing effects of gastric juice.

Most often, this drug is prescribed in a complex of preventive measures for mastopathy, although the positive effect of the drug on uterine fibroids and benign diseases of the cervix has been proven. The course of treatment lasts up to 90 days, consists in taking 1 capsule in the morning and evening after meals.

Many experts recommend including indole in the treatment of severe mastopathy. In this case, in addition to hormonal drugs, anti-inflammatory drugs and physiotherapy, women are advised to take 2 capsules of an active ingredient 2 times a day for 1 to 6 months.

How effective is the treatment for mastitis with Indole?

According to experts in the field of oncology, mastopathy is now found in more than half of all women. If the patient has a history of any pathology of the sexual sphere, then benign changes in the mammary glands will appear with almost 100% probability.

To provide medical and preventive care for this group of patients, the plant drug Indol has been proposed. Thanks to his mild correction of the percentage of estrogens in the patient's blood (namely, this hormone leads to the degeneration of breast cells), specialists can achieve the following positive effects:

  • Indole works perfectly in cystic-fibrous forms of mastopathy, reducing the density of the affected areas of the breast and correcting damage to the tissue structure.
  • When mastopathy is one of the main complaints of women are abnormal discharge from the nipples. Biologically active drug completely eliminates this problem.
  • The recommended remedy helps to reduce pain in the mammary glands. It helps to relieve swelling and abnormal nipple tension before menstruation.

In addition to directly affecting the cells and tissues of the female breast itself, Indol has a beneficial effect simply on the patient's general well-being. In women, performance increases, appetite improves, blood pressure fluctuations disappear completely.

При этом не стоит забывать о том, что по данным целой группы ученых, биологически активный препарат уменьшает вероятность ракового перерождения мастопатии на 30 — 40%. Следует отметить, что, учитывая практически минимальные побочные эффекты при приеме Индола, лекарство стоит включать в комплексную терапию и профилактические меры при патологии груди.

Негативные и положительные эффекты от лекарства

Сразу следует оговориться, что Индол и его аналоги не относятся к патентованным лекарственным препаратам. Dietary supplements have a certain therapeutic effect on the female body, but of course you should not expect an instant and obligatory result from them.

Indole is no exception to the rule. Medicinal natural remedy is advised to take a long time and only in combination with other specialized drugs.

Reviews of the considered drug from patients of gynecologists and oncologists receive a variety.

Some women consider these drugs as a panacea, carefully follow all instructions for its use and believe in the rapid cure of mastopathy. Another group of patients is more skeptical and prefers habitual hormonal and anti-inflammatory drugs.

After listening to their opinions, we can draw the main conclusion regarding the use of Indole in the treatment of mastitis. For most women, this remedy really helped, with many women emphasizing an improvement in overall well-being and a complete lack of side effects when taking a dietary supplement.

In the Russian Federation, attitudes toward biologically active drugs have recently changed. They have not yet come under a total ban, but their broad advertising is almost over. On this basis, the retail price of Indola in Russian pharmacies reaches 1,500 rubles, which, of course, not every woman can afford.

We recommend reading the article on the preparations for the treatment of mastopathy. From it you will learn about the symptoms of the disease, modern methods of treatment, recommended diet and vitamins.

Mastopathy is quite a serious disease that requires attention and constant treatment. Any biological plant substances can be included in the complex therapy only after consulting a doctor. Women need to remember that the use of dietary supplements does not cure the disease itself, these tools only help in the work of essential drugs.

Thus, despite the fact that the problems of the mammary glands and endometrial foci are different for their reasons, the complex treatment of mastopathy and.

Modern principles in the treatment of fibrocystic breast pathology. Fibrous-cystic form of mastopathy is also called mixed by doctors.

This form of mastopathy does not require specific treatment and practically passes after childbirth and lactation.

Welcome to the information site about the health of the female breast! All about the anatomy and enlargement of the mammary glands. The most common diseases of the breast, as well as their prevention and treatment. How to feed the baby and care for the breast during this period.

Information on this site is provided for reference purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

In the near future we will publish information.

Indol 3 carbinol NSP — a preparation containing highly purified indole 3 carbinol.

The clinical effects of idol-3-carbinol are realized through the following mechanisms of action:

  • normalization of estrogen metabolism by induction of active cytochrome CYP1A1, responsible for the predominant formation of 2-hydroxyestrone,
  • inhibition of pathological cell proliferation through the blockade of intracellular pathways of signal transmission from growth factors (EGF, IGF) and cytokines (tumor necrosis factor - a-interleukin-i),
  • stimulation of apoptosis in tumor cells due to the production of proapoptotic protein.

Over the long history of research, it has been proven that indole 3 carbinol possesses high antitumor activity, including in breast cells [5, 6]. However, data on the feasibility of using Indol 3 carbinol (NSP) in patients with PCM after surgical treatment of uterine fibroids in the amount of hysterectomy are not available in the literature, which was the reason for conducting a research study.

The purpose of this study was to study the effectiveness of the drug. Indol 3 carbinol NSP for the treatment of diffuse fibrocystic mastopathy in patients undergoing hysterectomy for symptomatic uterine fibroids.

Materials and research methods. The study included 83 patients aged 39–50 years who underwent surgical treatment in the amount of laparoscopic subtotal or total hysterectomy with preservation of uterine appendages about symptomatic uterine fibroids. All patients after 3 years after laparoscopic hysterectomy with a comprehensive examination of the mammary glands, including examination, palpation, mammography and ultrasound (US), was diagnosed with diffuse FCM (DKM).

Of the 83 patients included in the study, 39 women (46.9%) underwent hysterectomy at late reproductive age and 44 (53.1%) were operated on during premenopausal women.

Indications for surgical treatment in the examined patients are presented in table 1.

As follows from the table, among the indications for laparoscopic hysterectomy in patients with DFCM and uterine myoma, various menstrual irregularities leading to anemia and large uterine myomas with dysfunctional pelvic organs prevailed. The average size of uterus removed was 12–13 weeks of gestation. Indications for removal of the cervix were represented by dysplasia, leukoplakia, ectopia in combination with cicatricial deformity.

Table 1

Indications for laparoscopic hysterectomy

Large uterus myoma

Uterine fibroids, menometer

The rapid growth of uterine fibroids

The distribution of the patients included in the study according to the nosological forms of FCM is presented in Figure 1.

  • DFCM with a predominance of the glandular component
  • DFCM with a predominance of the cystic component
  • DFCM with a predominance of the fibrous component
  • Mixed form

Picture 1. Nosological forms of PCM in the examined patients

As can be seen from the data presented in the figure, among the pathological changes in the mammary glands, the mixed form of DFCM prevailed, noted in 36% of cases. DFCM with a predominance of the cystic component occurred in 31% of patients included in the study. The predominance of the glandular and fibrous components was observed in 25% and 8% of patients, respectively.

All 83 patients included in the study presented complaints of mastalgia of varying intensity. Of these, almost a third of women — 25 (30.1%), had painful sensations. About half of the patients - 41 (49.4%) characterized the pain in the mammary glands as moderate and, accordingly, 17 (20.5%) - as mild.

All patients, regardless of the form of Indole-3 mastopathy, carbinol NSP was prescribed at a dose of 400 mg per day (2 capsules 2 times per day) for six months with a dynamic assessment of the mammary glands after 3 and 6 months under ultrasound control. Since all patients had a mammogram before the start of the study, confirming the diagnosis of FCM, an x-ray examination of the mammary glands was not performed over time.

Research results

After a 3-month and 6-month course of treatment with Indol-3 carbinol NSP, the following results were obtained during the examination of the patients. It should be noted that two patients (DFKM with a predominance of the fibrous component and a mixed form of DFKM) due to the development of pronounced dyspeptic disorders (nausea, diarrhea) during treatment with Indol-3 carbinol NSP refused to take the drug for a long time and dropped out of the study. Another patient with DFKM with a predominance of the glandular component stopped taking the drug due to the development of an allergic reaction. The remaining 80 (96.4%) patients noted good tolerability of the drug.

The disappearance of pain after a 3-month course of Indol-3 carbinol NSP was found in 23 (28.7%) patients. Of these, 15 women initially complained of mild pain in the mammary glands and, accordingly, 8 - of the moderate nature of the pain.

Reduction of pain in the mammary glands occurred in 41 women (51.3%). Of these, 22 showed a dynamics of pain from moderate to mild, and 19 - from severe to moderate.

Accordingly, 16 patients (20.0%) for this period of observation did not subjectively noted any dynamics. In 11 of them, the painful sensations remained moderate, and in 5 of them - pronounced.

After 6 months of taking Indol-3 carbinol NSP, all 80 patients subjectively noted a positive trend. At the same time, the disappearance of pain in the mammary glands was generally observed in 61 women (76.3%), a decrease in pain in 19 patients (23.7%). Among the latter, mild pain in the mammary glands was noted in 14 cases (17.5%), and only 5 women (6.2%) experienced moderate pain. Thus, no patient experienced severe pain after 6 months of taking Indol-3 carbinol NSP.

The dynamics of pain in the mammary glands in the examined patients while receiving Indol-3 carbinol NSP is presented in Figure 2.

Figure 2.The dynamics of pain in the mammary glands in the examined patients

Objectively, the positive dynamics of treatment was determined during examination, palpation and ultrasound of the mammary glands. The criteria for the positive effect of taking Indol-3 carbinol NSP were: reduction of edema, pain, heterogeneity of the mammary gland structure, reduction of tissue echogenicity, decrease in the size of cysts in diameter by 2-3 mm (from 0–1.5 mm to 0.7– 1.2 mm) and the diameter of the milky ducts, improving the severity of connective tissue pattern.

In general, an objective positive trend, after 3 and 6 months after the start of treatment, was noted in 58 (72.5%) and 74 (92.5%) patients, respectively.

The best effect of treatment after 3 months of taking the drug was observed in patients with DFCM with a predominance of the cystic component: positive dynamics were objectively stated in all 26 women.

In patients with a mixed form of DFCM and DFCM with a predominance of the glandular component, the positive dynamics after 3 months of taking Indol-3 carbinol NSP was established in 19 (67.9%) and 13 (65.0%) cases, respectively.

In 6 patients DFKM with a predominance of the fibrous component, despite the stated subjective reduction of pain, objectively any dynamics was not detected.

After 6 months of taking Indol-3 carbinol NSP, positive dynamics in the state of the mammary glands was observed in all patients with a mixed form of DFCM and DFCM with a predominance of the glandular component. The maximum effect was also achieved in all patients with DFCM with a predominance of the cystic component. At the same time, in patients with DFCM with a predominance of the fibrous component, objectively, any dynamics were still not established.

Positive objective dynamics of the mammary glands after 3 and 6 months after the start of Indol-3 carbinol NSP with various forms DFKM presented in Figure 3.

Figure 3.Positive objective dynamics of the state of the mammary glands against the background of Indol-3 carbinol NSP intake

1. DFCM SF - mixed form of diffuse FCM,

2. DFCM LCD - diffuse FCM with a predominance of the glandular component,

3. DFCM QC - diffuse FCM with a predominance of the cystic component.

Discussion

To date, worldwide hysterectomy for symptomatic uterine fibroids remains the most common operation on the pelvic organs in women. In recent years, there is a clear upward trend in the number of conducted hysterectomies in women of late reproductive age. The literature presents in sufficient detail the systemic changes in the woman’s body after hysterectomy, concerning the anatomical and functional state of the ovaries and urinary tract, as well as neuro-vegetative and sexual dysfunction [7]. Numerous studies in this area allowed us to determine possible ways to correct developing functional disorders. At the same time, the prevention and treatment of combined breast diseases in women undergoing surgical treatment of uterine fibroids is not given due attention.

As is known, patients with uterine myoma, who are supposed to undergo hysterectomy with preservation of uterine appendages, are at increased risk for the occurrence and progression of dysplasias of the mammary glands in the postoperative period. In a number of studies, it has been proven that uterine myoma is most often combined with proliferative forms of fibrocystic mastopathy, in which the relative risk of developing breast cancer is increased [8, 9]. This circumstance necessitates consideration of the common pathogenetic mechanisms of uterine fibroids and mastopathy and the implementation of an integrated approach when choosing a method of treatment in these patients.

In the present study, the feasibility of using Indol 3 carbinol NSP in patients undergoing hysterectomy for symptomatic uterine fibroids diagnosed with DFBC was evaluated.

The combination of proliferative processes in the mammary glands and myometrium in women is associated with the universality of the mechanisms of estrogen-dependent proliferation and apoptosis [9, 10]. Indole-3 carbinol NSP is a tool that is capable of multiple pharmacological correction of molecular biological processes (normalization of estrogen metabolism, inhibition of pathological cell proliferation, induction of apoptosis). This circumstance determines its priority use in patients with PCM and uterine myoma.

The obtained results are consistent with the data on the clinical efficacy of Indol 3 carbinol NSP in the treatment of various forms of FCM, presented in the studies of domestic authors [1, 5, 6]: positive subjective dynamics in the form of disappearance and reduction of the nature of mastalgia were noted in almost all patients regardless of the form of PCM . According to Yu.V. Bikeeva, N.F. Makovetskaya (“Use of Indol-3 carbinol NSP in the treatment of various forms of mastitis”, State Healthcare Institution “Samara Regional Clinical Oncologic Dispensary”) in the treatment of 87 patients with diffuse mastopathy with Indol-3 carbinol NSP, the overall positive effect was noted in 95.4%. Positive objective dynamics of the state of the mammary glands according to the results of this study takes place in 92.5% of observations. The effect of Indol-3 carbinol NSP develops gradually, reaching a maximum 6 months after the start of use. In this study, the maximum clinical effect was achieved in patients with DFKM with a predominance of the cystic component.

Thus, the results of the study confirmed the clinical efficacy and feasibility of prescribing the drug Indol 3 carbinol NSP in patients with PCM after surgical treatment of uterine fibroids in the volume of hysterectomy.

Bibliography

1. Vysotskaya, I.V. Modern possibilities of treatment of fibrocystic disease // Tumors of the female reproductive system. 2011. No. 1, 2. P. 44–46.

2. Kogan, I.Yu. Mastopathy: new approaches to diagnosis and pathogenetic therapy // Journal of Obstetrics and Female Diseases. 2011. Tom LIX, vol. 1. P. 66–71.

3. Radzinsky, V.E. Mammary glands and gynecological diseases / V.E. Radzinsky. ZM.-Status Praesens. 2010. 303 s.

4. Ashrafyan, LA, Kiselev, V.I. Modern possibilities of prevention and early diagnosis of precancer and cancer of the reproductive organs // Obstetrics and Gynecology. 2009. No. 4. P.24-29.

5. Lyashenko, A.A., Kiselev, V.I., Severin E.S. Indol-3-carbinol (Indol-3 carbinol NSP): therapeutic and prophylactic effects on breast tumors // Molecular medicine. 2005. No. 2. P.20-25.

6. Rozhkova, N.I., Meskikh, E.V. Treatment of benign breast diseases // Tumors of the female reproductive system. 2007. No. 4. P.23-24.

7. Vikhlyaeva, E.M. Hysterectomy and its consequences // in the book. Guidance on the diagnosis and treatment of uterine leiomyoma. M., MEDpress-inform. 2004. p. 319–3b4.

8. Smetnik, V.P., Konovalova, V.N., Leonova, N.Yu. Pathophysiology and therapy of benign breast diseases: controversial issues // Reproduction problems. 2009. No. 1. P.93–100.

9. Baylyuk, E.N. Clinical and morphological features of proliferative processes in the mammary gland in patients with uterine myoma // Journal of Obstetrics and Female Diseases. 2011. Tom LIX, vol. 1. P. 98–106.

10. Idrisova, EA, Badgoeva, O.Kh., Vlasov, R.S., Makarova, I.I., Guriev, T.D. The combination of hyperproliferative diseases of the uterus and mammary glands: the possibilities of targeted therapy // Problems of reproduction: Proceedings of the IV International Congress on Reproductive Medicine. Specialist. issue 2010. pp. 186–187.

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Characterization of indole-3-carbinol-containing dietary supplements

In the treatment of benign dysplasia of the breast, we used three biologically active food supplements containing indole-3-carbinol: Stella, Indinol and Estrovel (Table 1).

Stella is available in the form of trichromatic capsules of 400 mg. The yellow capsule contains 100 mg of indole-3-carbinol contained in cruciferous vegetables. Indole-3-carbinol has the following effects:

1) stimulates the 2-hydroxy estrogen detoxification path,
2) modulates estrogen receptors (an antagonist of alpha receptors of estrogen),
3) stimulates apoptosis of cancer cells,
4) inhibits tumor angiogenesis,
5) antioxidant.

The green capsule contains 60 mg of epigallocatechin-3-gallate contained in green tea. Epigallocatechin-3-gallate has the following effects:

1) reduces the production of the enzyme aromatase, which contributes to the conversion of androgens into estrogens,
2) selectively reduces the growth rate of blood vessels in tumors, that is, suppresses the production of vascular endothelial growth factor (VEGF).

Капсула красного цвета содержит 60 мг изофлавонов сои (генистеина и дзадзеина), которые обладают следующими эффектами:

1) стимулируют 2-гидроксилирование эстрогенов,
2) конкурентно связываются с рецепторами эстрогенов,
3) снижают секрецию 4-гидрокси-эстрогенов,
4) повышают продукцию секс-связывающего глобулина.

Stella is recommended to normalize the exchange of estrogens (restore the normal ratio of 2-hydroxyestrogen and 16-alpha hydroxyestrogen and reduce the production of 4-hydroxyestrogens), to improve the functional state of the female reproductive system and reduce the risk of hormone-dependent diseases of the female reproductive system, such as myoma, mastopathy , endometriosis and as part of complex therapy of the latter. Recommended doses: 1 capsule in yellow each in the morning, 1 capsule in green in the afternoon and 1 capsule in red in the evening for 1 month. If necessary, admission can be extended to 3–6 months, 1–2 times a year at equal intervals [18].

Indinol is available in 300 mg capsules. Each capsule contains 90 mg of indole-3-carbinol and excipients, including magnesium stearate 3 mg.

Indinol should be taken for prophylaxis and as part of the comprehensive treatment of benign breast diseases. It is also recommended to take Indinol when combining benign dysplasias of the mammary glands with other diseases of the female reproductive system: endometriosis, uterine fibromyoma, endometrial hyperplasia, cervical dysplasia, genital condyloma.

ESTROVEL is available in tablets of 500 mg. It contains indole-3-carbinol (25 mg per tablet), tsimifuga racimose extract (30 mg per tablet), wild yam root extract (50 mg), soybean isoflavones (25 mg), vitamins B6, E, folic acid, and other auxiliary components in small quantities.

Tsimifuga racimoza and wild yam root have long been used to treat menopausal disorders in women. Soybean isoflavones are phytoestrogens and compensate for the negative effects of estrogen in its excess. Therefore, in addition to the therapeutic effect on the breast tissue, Estrovel contributes to the normalization of unstable blood pressure, reduces the intensity of headache attacks, reduces the frequency of hot flashes in women with neurovegetative disorders during menopause. The recommended dose of Estrovela 1-2 tablets per day for 2 months.

In many cities of Russia there are no large breast centers. Identification, follow-up and treatment of patients with dyshormonal dysplasia of the breast is carried out by local obstetrician-gynecologists. In turn, the analysis of outpatient cards of a dispensary group of patients showed that the treatment of diseases of the mammary glands is not always adequate to their objective state, changes in ultrasound and mammography and the presence of concomitant gynecological pathology. Therefore, research on the use of indole-3-carbinol-containing dietary supplements will help a more rational treatment of women with breast diseases.

Purpose of the study: to analyze the effectiveness of treatment of women of different age groups with dyshormonal dysplasia of mammary glands with indole-3-carbinol-containing dietary supplements.

Patients and methods. Totally, indole-3-carbinol-containing dietary supplements (as part of complex therapy) were treated with 192 women registered with a breast doctor with a diagnosis of benign dyshormonal dysplasia of the mammary glands. Age of patients from 17 to 56 years. The duration of observation at the mammologist from 1 year to 19 years. Ultrasound examination of the mammary glands was performed for all patients. Women 40 years and older - ultrasound and mammography.

The 1st group consisted of 52 women aged from 17 to 35 years. The group took Stella for 3 months.

Group 2 consisted of 103 patients aged from 17 to 50 years who received Indinol. Patients of reproductive age were 48, pre-menopausal and menopausal age - 55.

The 3rd group included 37 women aged from 50 to 56 years who were treated with Estrowel.

Evaluation of the results of therapy included the analysis of the intensity of pain in the mammary glands, the state of the structure of the breast tissue during the examination and palpation, and the change in the breast tissue during the ultrasound examination.

The pain intensity was estimated using a verbal scale in points from 0 to 4:

  • 0 points - no pain
  • 1 point - mild pain,
  • 2 points - moderate pain,
  • 3 points - severe pain,
  • 4 points - unbearable pain.

The state of the breast tissue was assessed according to the inspection and palpation in points from 0 to 6 [11]:

  • 0 points - no pathological process,
  • 1 point - mild diffuse fibroadenomatosis,
  • 2 points - moderate diffuse fibroadenomatosis,
  • 3 points - pronounced diffuse cystic or fibrous fibroadenomatosis,
  • 4 points - pronounced diffuse cystic or fibrous fibroadenomatosis,
  • 5 points - localized fibroadenomatosis against a diffuse background,
  • 6 points - localized fibroadenomatosis against a diffuse background.

The results and discussion

The 1st group included women of reproductive age. All patients complained of severe pain in the mammary glands before menstruation for 7–10 days (78%) or moderate pain not associated with the cycle (22%). On examination, lumpy seals were more common in the mammary glands - 5 points (63%) and medium-grain seals - 4 points (37%). In 80% of cases when viewed from the breast tissue is dense, swollen. When ultrasound examination of all women, the picture corresponded to the mixed (fibrocystic) form of mastitis. The maximum size of the cyst is 14.5 mm.

The women of the 1st group were prescribed Stella capsules, 1 pc each. 3 times a day for 1 month (according to the instructions and voluntary certification, translated into indole-3-carbinol 100 mg). This treatment was performed as part of an integrated therapy that included vitamins and trace elements. With a strong pain syndrome, Mastofit Evalar cream was applied topically 2 times a day, 7–10 days a month.

All women underwent treatment well. Many noted the modern color design of tablets, which increased the motivation of patients to consistent treatment. Improvement in the condition occurred in 72% of women. Pain in the mammary glands, both premenstrual and unrelated to the cycle, decreased to mild, although the pain syndrome was not completely stopped. 26% of patients did not report any significant improvement. And 1 patient (2%) after treatment complained of increased pain in the mammary glands before menstruation.

On examination, an improvement in the state of the mammary glands was noted in 86% of women. Breast tissue has become softer and more uniform (3-4 points). Lumpy seal retained in 27% of patients. With the control ultrasound, no significant changes were noted: tissue fibrosis remained, the size of the cysts did not decrease. Patients were advised to continue the course for 3–6 months.

All women of the 2nd group complained of pain in the mammary glands. Women of reproductive age were disturbed by pains before menstruation for 10–14 days. Patients described the intensity of pain as moderate (40%) and strong (60%). On examination, the structure of the mammary glands is dense-grained, heterogeneous, which corresponded to 3-4 points (56%) and 5 points (44%). On ultrasound, women of reproductive age have fibrous changes and cysts from 0.7 to 1.2 cm. In women of pre- and menopausal age, an ultrasound and mammography study showed a fibrocystic or fibrous form of mastitis with manifestations of fatty involution.

When prescribing Indinol, dose adjustment and duration of treatment were prescribed. The instructions attached to the package, the recommended dose of 1 capsule per day 2-3 weeks. But in the literature devoted to the treatment of breast diseases, the doses used range from 2 to 4 capsules per day with a duration of administration from 1 to 6 months [9, 12-14]. There is evidence of the dependence of the applied dose on the weight of the patient. So, for women up to 60 kg, it is enough to take 1 capsule 3 times a day, and women over 60 kg need 2 capsules 2 times a day [14]. But such an increase in the dose and duration of treatment requires additional financial costs, which limits the range of patients who can be prescribed treatment.

We decided to stop on the average dose - 300 mg (1 capsule) 2 times a day (in terms of indole-3-carbinol 180 mg). With a strong pain syndrome, Mastofit Evalar cream was also prescribed topically to the mammary glands 2 times a day 7–10 days before menstruation.

All patients underwent a three-month course of treatment. Allergic reactions and adverse symptoms were observed. In 61% of women of reproductive age, premenstrual pain syndrome significantly decreased to mild pain 3-5 days before menstruation. 52% of women of pre- and climacteric age noted both a decrease or disappearance of pain, and a decrease in such sensations in the mammary glands as a burning sensation, tingling, itching.

On examination of the mammary glands, a softer and more uniform tissue structure (2-3 points) was observed in 83% of women of reproductive age and 64% of women of premenopausal menopausal age. The control ultrasound showed no visible positive changes in women of both age groups: cysts of the same size, fibrosis in the same volume.

According to the literature, the maximum effect in the treatment of patients is noted by the 6th month. Disappearance of mastalgia and mastodynia is observed in 70.4–90.5% of patients [12–14]. Moreover, 100% efficacy of treatment was observed in patients with glandular mastopathy [15]. Improvement of the mammographic pattern in 33.7% of patients is observed by the 12th month after treatment [16]. Therefore, women in this group were recommended to continue treatment with indinol.

The women of the 3rd group complained of severe (35%) and moderate (65%) breast pains and symptoms characteristic of the menopausal syndrome: hot flashes, fever, palpitations, sweating. Estrovel was prescribed to patients as 1 tablet 2 times a day for 3 months (according to instructions and voluntary certification, in terms of indole-3-carbinol 50 mg). With severe pain in the mammary glands, Mastofit Evalar cream was used topically twice a day 7–10 days before menstruation.

On examination, the mammary glands had a fine or medium-grained structure, a dense consistency (2-3 points). When ultrasound - fibrous changes in breast tissue on the background of involution. A similar pattern was obtained on mammograms.

In the available literature on the use of Estrovela in women in the period of perimenopause, there is a good tolerability and 100% effectiveness against neurovegetative symptoms [17].

During the treatment of our women of 37 people, one patient experienced an exacerbation of chronic cholecystopancreatitis. Estrovel had to cancel. The remaining 36 women underwent treatment well. After three months of therapy, 68% of patients noted an improvement in their state of health: pain and discomfort in the mammary glands decreased. Severe pain disturbed only 8% of patients. Neurovegetative symptoms became less pronounced in 68% of women, and 32% noted the disappearance of hot flashes and heat. On examination, the mammary glands became softer and more homogeneous (1–2 points) in 62% of women (Table 2). But with the control ultrasound there was no obvious positive dynamics.

  1. Indole-3-carbinol-containing dietary supplements are highly effective in the complex treatment of patients with benign dyshormonal dysplasia of the mammary glands.
  2. Treatment of indole-3-carbinol-containing dietary supplements is well tolerated by women of reproductive, preclimacteric and menopausal age.
  3. Improvement of the subjective state in the form of a decrease in the intensity and duration of pain in the mammary glands was observed in 61–78% of women of reproductive age and 52–68% of women of pre- and menopausal age. Improvement of objective indicators in the form of an improvement in the structure of breast tissue was noted in 83–86% of women of reproductive age and 62–64% of women of pre- and menopausal age.
  4. To achieve maximum effectiveness from therapy and positive dynamics of the objective state of the mammary gland according to ultrasound and mammography, it is necessary to continue treatment (as part of complex therapy) with indole-3-carbinol-containing dietary supplements for up to 6 months.

Literature

  1. Letyagin V.P., Vysotskaya I.V., Kim E.A. Pogodina E.M., Maksimov K.V. Phytotherapy of diffuse fibrocystic disease. M .: ABV-press, 2008. 28 p.
  2. Mustafin Ch. K., Kuznetsova S. V. Dishormonal diseases of the breast. Clinical Guide / Ed. Pinhosevich, E.G.M., 2009. 126 p.
  3. Vasilevsky A.V., Kozlovskaya N.A., Ilkevich A.G. and other Benign and malignant diseases of the breast: A Handbook for students and doctors. Ed. L. A. Putyrsky, Yu. L. Putyrsky. M .: LLC “Med. inform Agency, 2008. 336 p.
  4. Chistyakov S. S., Selchuk V. Yu., Grebennikova O. P. Cancer and benign breast tumors: A manual for the system of postgraduate vocational education. Ed. S. Chistyakov. Moscow: Academy of Authors, 2009. 120 p.
  5. Gilyazutdinov I. A., Khaskhanov R. Sh. Benign breast tumors: a guide for physicians. Kazan: Medliterature, 2007. 216 p.
  6. Vysotskaya I.V. Modern possibilities of treatment of fibrocystic disease // Tumors of the female reproductive system. 2009. № 1–2. Pp. 44–46.
  7. Vozny E.K., Belonogov A.V., Satyrov E.F., Yurgina O.V. Breast cancer (modern approaches). Clinical mammology. Thematic collection. 1st edition. Moscow: Firma Strom LLC, 2005. 181–189.
  8. Speirs V., Atkin S. L. Production of the VGEF and the expression of the VEGF receptors Ade-1 and KDR in the epithelial cell line and stromal cells derived from breast tumors // Br J Cancer. 1999. № 80 (5-6). 898–903.
  9. Kiselev I.V., Lyashenko A.A. Indinol - regulator of proliferative processes in the reproductive system. M .: ZAO MiraxPharma, 2008. 48 p.
  10. L. Sidorenko Breast. How to protect yourself from cancer. A book for every woman. St. Petersburg: Folio Press. 1998. 704 p.
  11. Rakhimzhanova R.I., Suleimenova E.V., Mayer K.M., Solomonova A.M. Experience with indinol in the treatment of various forms of mastopathy in Kazakhstan. Organizational, medical and technical aspects of clinical mammology. Mater 5 All-Russia. scientific and practical conf. from Intern. participation. M., 2007. 130–132.
  12. Rozhkova N. I., Meskikh E. V. Evaluation of the effectiveness of the drug indinol in the treatment of various forms of mastopathy. Organizational, medical and technical aspects of clinical mammology. Mater 5 All-Russia. scientific and practical conf. from Intern. participation. M., 2007. 149-152.
  13. N. I. Rozhkova, L. M. Burdina, V. P. Smetnik et al. Complex allopathic and homeopathic treatment of mastopathy // Bulletin of the Russian Association of Radiologists. 2009. No. 1. 148-152.
  14. Zulkarnayeva E.T., Khakimova R.H., Lapan E.I., Blagodetev I.L. Indinol-3-carbinol in the treatment of benign breast diseases // Tumors of the female reproductive system. 2008. No. 3. P. 50–54.
  15. Kulagina N.V. Therapy of fibrocystic breast disease in patients with uterine myoma // Tumors of the female reproductive system. 2010. No. 1. P. 40–43.
  16. Kulchavenya E. V., Brizhatyuk E. V., Breusov A. A. The effectiveness of the dietary supplement Estrovel in the treatment of women with chronic cystitis during the perimenopause // Obstetrics and Gynecology. 2009. No. 3. P. 69–71.
  17. Bradlow H. L., Telang N. T., Sepkowic D. W. et al. // J Endocrinol. 1996, 150: 259–265.
  18. ROAG information letter. M., 2009.

E. A. Sukhareva *,Candidate of Medical Sciences
L.A. Ponomareva **,doctor of medicine, professor
S.V. Kozlov **,doctor of medicine, professor

* MUZ City Polyclinic № 1, Sizran
** GBOU VPO SSMU them. V.I. Razumovsky Ministry of Health and Social Development of Russia, Samara

When used "Indole"

The main active component of the drug is indole-3-carbinol. This substance blocks the activity of alpha receptors for estrogens in tumor cells, improves the efficiency of the liver, and negatively affects the development of cancer cells. In one capsule means is the daily intake of indole-3-carbinol. Also, the active components of this drug are powder and broccoli seedlings extract, ascorbyl palmitate.

The natural components of this dietary supplement are phytoestrogens and due to this they have a positive effect on the woman's body. With a lack of their own estrogen, their intake makes it possible to fill the deficiency, with an excess - phytoestrogens will compete with real hormones for receptors and thus reduce their level to normal. Excess estrogen provokes the development of tumors in the female reproductive organs - the ovaries, uterus, mammary glands. Due to the above properties, “Indol” is considered to be convenient for use and quite effective. anti-cancer agent.

The main principle of the drug is based on the cleaning of organs and tissues from toxic substances accumulated over the course of a lifetime. These properties make it useful in the treatment of liver diseases (hepatitis, cirrhosis), food poisoning, allergic reactions. Especially widely "Indole" used in gynecology. The indications for its use are as follows:

  • premenstrual syndrome,
  • cervical erosion,
  • hormonal stabilization,
  • disruptions of the menstrual cycle caused by hyperestrogenic and gestagen deficiency,
  • fibroids and fibroids,
  • fibrocystic mastopathy,
  • polycystic ovaries,
  • endometriosis,
  • endometrial hyperplasia,
  • human papillomavirus infection
  • prophylaxis and concomitant treatment of tumors in the breast, ovaries, uterus,
  • increase female fertility
  • liver failure,
  • intoxication caused by various poisonings,
  • long-term use of toxic drugs.

In the treatment of these diseases should not be limited to biologically active additives. The greatest effectiveness of their use can be obtained as a result of complex therapy. Фармацевтические средства, а при необходимости и хирургическое вмешательство являются основными компонентами лечения. Употребление биологически активной добавки может усилить их эффективность.

Contraindications

Как растительный препарат «Индол» имеет незначительное число противопоказаний. These include склонность пациентки к сильным аллергическим реакциям, особенно на цветение крестоцветных растений. Также не следует употреблять данную пищевую добавку во время беременности и при грудном вскармливании. The effect of “Indole” on the child being carried and the mother’s milk is not fully understood. In addition, it should be noted that the simultaneous intake of dietary supplements and drugs that affect the acidity of gastric juice, can reduce the effectiveness of therapy. This remedy is contraindicated in children under 18 years.

Instructions for use "Indole Forte Evalar"

The drug Indol Forte Evalar is available in the form of capsules of 0.23 g. Pharmacies have packs of 30 and 60 each. Each tablet contains 100 mg of indole-3-carbinol, 92.5 mg of plant extracts, as well as auxiliary substances typical for dietary supplements. Adults need only take 1 capsule of Indol Forte per day with meals. Sometimes, at the insistence of the attending physician, the daily dose of the dietary supplement may be increased. For a tangible health effect, it is desirable to undergo a monthly course of purification, and then repeat if necessary.

The use of "Indole" during menstruation

Since this drug has a direct effect on the monthly cycle, some women doubt whether it should be taken during critical days. As a dietary supplement, this drug does not require adherence to a strict schedule of receptions. You can drink “indole” during all phases of the cycle.

Influence on a menstrual cycle and profusion of monthly

Indol has a positive effect on the health of women with hyperestrogenia. Excess estrogen provokes endometrial pathologies and, as a result, painful and heavy bleeding.

Also, the drug regulates the duration of the cycle, bringing it back to normal. The spotting disappears the day before and after the menstruation, the excess duration of the menses is reduced. The positive effect is manifested in the mitigation of premenstrual syndrome. Women taking Indol are less affected by emotional highs.

Drugs analogues

"Indol" has several drugs with the same mechanism of influence and almost the same amount of the main active ingredient. These funds are distinguished by additional components in the composition. The choice of drug is carried out depending on the relevance of a particular herbal supplement for a particular disease. Most often, as a replacement, use such dietary supplements:

  • "Stella". The composition of this drug are extracts of soy and green tea. The tool is effective in the treatment of tumors of different nature and other gynecological diseases. Multi-colored tablets are taken 3 times a day with meals. The course of taking "Stella" is designed for 3 months and a break of six months,
  • Estrovel - in the composition of the drug, in addition to the main component, boron, vitamins B6, B9, E, extract of cimicifuga, soy, yam and a number of amino acids are present. This tool is assigned to women who are difficult to endure menopausal changes. Regular use significantly reduces the intensity and number of tides, regulates blood pressure and heart function. With the help of "Estrovela" women more easily cope with bouts of irritability and hysterical states accompanying hormonal changes in the body. Also, this tool is used in the postoperative period after removal of the ovaries. In addition to the above therapeutic effects, Estrovel is also an anticancer drug,
  • "Indinol" - in the composition of the medicament there is a single active ingredient - indole-3-carbinol. The dosage of this tool - 2 tablets per day for 3-6 months. The main function of "Indinol" is to prevent cancer and benign tumors. Also, this dietary supplement is used to enhance the effect of anti-cancer therapy,
  • "Indol plus" - The composition of this drug supplemented with artichoke leaf extract. This plant, like broccoli, contains a large amount of indole-3-carbinol. Due to this, the effect of taking Indole Plus is faster and more persistent. The additive is used to stabilize the hormonal background, improve overall health through detoxification. Indol Plus has a positive effect on the digestive and excretory systems, helping to rejuvenate and heal the body. This drug is taken 1-2 capsules per day for 1-2 months.

Patient Reviews

Most women note a clear health effect after the Indola course. Many of those who complained of swelling and pain in the mammary glands before menstruation, noted a decrease in discomfort. Also, this tool effectively copes with mastopathy. Some patients who had breast surgery were shown that after the course “Indole” could not resort to surgery or postpone it for a long time. After 2-3 months of use of this drug, women note an improvement in their psycho-emotional state during premenstrual syndrome and during menopause. The stabilization of the hormonal balance has a positive effect on the well-being and mood of those taking Indol.

Natalia Evgenievna Pokhodilova

Psychologist, Kinesiologist Online consultant. Specialist from the website b17.ru

Well this is just a dietary supplement. Absolutely not connected. I drink it all right.

_you have no blood left.
urgently drink the blood of her husband.

Well this is just a dietary supplement. Absolutely not connected. I drink it all right.

My cycle from Indinol did not go astray. However, it is possible that everything is individual. However, in any case it is worth to consult a doctor.

Why drink this scam?

Who knows why the thread disappears completely or scanty periods during the reception of indinol? Who had it? I have mastopathy and endometriosis. Before the doctor I can not reach the queue until the end of the month

Related topics

thanks who answered

My ultrasound showed (hyperplasia of endometrium) and laid on curettage on the advice of a gynecologist to cut through 60 capsules of Indinol, but so far I have not felt any changes and now I’m wondering whether it is worth spending any more. But after scraping, I lost the pain on the coccyx, but they started to start drinking the capsules again and do not understand what was happening and why.

I have lost my period's identity, should now come but no response is not a greeting, the chest does not fill, and the stomach does not hurt at all.

And how is it all over with you? I have a one-on-one situation! Months are always 28 days, and there is already a 5 day delay, tests are negative, the chest is not full for the first time in my life, I don’t know what to think!

I have a similar situation, I began to take indinol before the menstrual period and now there are no months for 2.5 months. Has thought already the climax has come :-). I am 32 years old. Probably need to still see a doctor

a delay of 30 days on the background of taking indinol. fearfully

Indinol to drink during menstruation or stop for a time ms? Answer me. Pliz

I also have a 3 day delay, although I only drank indinol for two weeks, the test is negative))) In medical forums there is no answer to this question, what to think and I don’t know.

The situation is similar: a delay of 6 days after almost a month of taking indinol. In addition, itchy body at night, I am allergic and I have some medicines and dietary supplements cause itching. I decided that I would finish the packaging (120 capsules) and I wouldn’t drink anymore.

Indinol to drink during menstruation or stop for a time ms? Answer me. Pliz

Indinol to drink during menstruation or stop for a time ms? Answer me. Pliz

Indinol helped me to cure HPV I drank it for 6 months, I stopped drinking and the delay of menstruation was gone for 14 days ((test negative !! I don’t know what to do.

Saw indinol 3 months, did not affect the cycle.

Indinol to drink during menstruation or stop for a time ms? Answer me. Pliz

I drink indinol + epigalat for the 4th month (before this was Yarin). With the cycle I became a complete mess - then 25 days, the last month was 38 in total - I already thought that I could not wait for them. Now here again, the 32nd day of the cycle is coming - and silence. Tolley in the body otkhodnyaki after 3 years of taking Yarina, toli Indinol affects, toli both.

Indinol helped me to cure HPV I drank it for 6 months, I stopped drinking and the delay of menstruation was gone for 14 days ((test negative !! I don’t know what to do.

Saw indinol from a tumor in the chest, 3 cans of 120 capsules. The first time delay was 42 years, the cycle became 1 time in seven months, in the seventh month they came when there was a break from indinol (I now understood this) I went to the doctor, nobody suggested, all with one voice - early menopause. Could not be associated with the reception of indinol. Now I'm sure. Matter in it!

Girls who have stretched the cycle, how I envy you. I have adenomyosis, very heavy periods, such that I don’t go out of the house (the cycle is 26-28 days in total. Hormones didn’t fit me. The doctor prescribed Indinol + ipigallat. I’ve drunk for 4 cycles completely ((((


The situation is similar: a delay of 6 days after almost a month of taking indinol. In addition, itchy body at night, I am allergic and I have some medicines and dietary supplements cause itching. I decided that I would finish the packaging (120 capsules) and I wouldn’t drink anymore.

I have mastopathy and endometriosis, a cyst, a slight delay, ooooochen scanty menses, there is practically no ICP on the background of indinol

She began to drink indinol and immediately began her period. although there were only 2 weeks ago. I think whether to continue if he acts like that? Discharged for prophylaxis in connection with mastopathy.

I drink from E + I myoma. 2 weeks already. The cycle has not changed. But today vomited in the morning. That capsules Indinola ((((what is the reason? Can reduce the dose?

I have cut three months of indole-3 and green tea extract + evening primrose oil 1 pack, now the delay is already 20 days, the pregnancy is negative !! treated mastopathy and endometriosis! internally I feel better, but the absence of menstruation is annoying.

Took indinol from HPV month. Also a delay already a week, for the first time in all the time (((I don’t find a place for myself. Pregnancy is excluded

INSTRUCTION for medical use of the drug Indinol® Forto (Indinol® Forto)
Side effect From the reproductive system: menstrual disorders in the form of lengthening or shortening. On the part of the digestive system: pain in the epigastrium. Laboratory indicators: an increase in the concentration of thyrotropic and follicle-stimulating hormones, prolactin and estradiol, a decrease in the concentration of creatinine, eosinophilia. Other: weight loss.
Source: http://www.tiensmed.ru/news/indinol-ab
Same problem! The delay is 2 days, nothing hurts, the chest has stopped hurting.

Girls who have stretched the cycle, how I envy you. I have adenomyosis, very heavy periods, such that I don’t go out of the house (the cycle is 26-28 days in total. Hormones didn’t fit me. The doctor prescribed Indinol + ipigallat. I’ve drunk for 4 cycles completely ((((

I drink Indinol forto. In the first month after taking menstruation with delay, scanty, no symptoms. Now I drink the second month and also a delay and no symptoms by the beginning of the month. And nothing surprising. "The basis of the therapeutic effect of Indinol® Forto is its anti-estrogenic and anti-proliferative effect." I think it is necessary to change the drug. Saw as prescribed by a doctor. Read the instructions for the drug!

I drink Indinol forto. In the first month after taking menstruation with delay, scanty, no symptoms. Now I drink the second month and also a delay and no symptoms by the beginning of the month. And nothing surprising. "The basis of the therapeutic effect of Indinol® Forto is its anti-estrogenic and anti-proliferative effect." I think it is necessary to change the drug. Saw as prescribed by a doctor. Read the instructions for the drug!

Also disappeared after indinol. 19 day delay. Before, indinol drank together with the epilagate and everything was normal .. 1 month indinol drank alone and now it is delayed. Scary too

I have been drinking indinol forto for almost half a year. Mastopathy was gone, but with her and her period. Artificial menopause began. I experienced all his horror with ebbs and flows. Sensations from a burning stove in a snowdrift of snow. That wild heat, the wild cold! During the night I woke up to 7 times in a wet and sticky sweat, then right there from the cold, I couldn’t get a grudge against a tooth. And as a condition such that I did not want to live. Such thoughts went to my head, almost putting my hands on myself. looked swollen and scary. I suffered endlessly. Not yet thought to cancel. Menstruation gradually recovered, but went with delays of up to 40-60 days during the year, and then disappeared altogether. Ultrasound in the ovaries ended follicles. Now, the monthly will never come. I think that taking this drug, I approached menopause for several years.

I have been drinking indinol forto for almost half a year. Mastopathy was gone, but with her and her period. Artificial menopause began. I experienced all his horror with ebbs and flows. Sensations from a burning stove in a snowdrift of snow. That wild heat, the wild cold! During the night I woke up to 7 times in a wet and sticky sweat, then right there from the cold, I couldn’t get a grudge against a tooth. And as a condition such that I did not want to live. Such thoughts went to my head, almost putting my hands on myself. looked swollen and scary. I suffered endlessly. Not yet thought to cancel. Menstruation gradually recovered, but went with delays of up to 40-60 days during the year, and then disappeared altogether. Ultrasound in the ovaries ended follicles. Now, the monthly will never come. I think that taking this drug, I approached menopause for several years.

I have cut three months of indole-3 and green tea extract + evening primrose oil 1 pack, now the delay is already 20 days, the pregnancy is negative !! treated mastopathy and endometriosis! internally I feel better, but the absence of menstruation is annoying.

I have been drinking indinol forto for almost half a year. Mastopathy was gone, but with her and her period. Artificial menopause began. I experienced all his horror with ebbs and flows. Sensations from a burning stove in a snowdrift of snow. That wild heat, the wild cold! During the night I woke up to 7 times in a wet and sticky sweat, then right there from the cold, I couldn’t get a grudge against a tooth. And as a condition such that I did not want to live. Such thoughts went to my head, almost putting my hands on myself. looked swollen and scary. I suffered endlessly. Not yet thought to cancel. Menstruation gradually recovered, but went with delays of up to 40-60 days during the year, and then disappeared altogether. Ultrasound in the ovaries ended follicles. Now, the monthly will never come. I think that taking this drug, I approached menopause for several years.

Saw Indinol 3 months. From the first month of admission increased and prolonged periods. In the second month of the month were very strong, on the verge and with clots. The third month brought intestinal upset and on the first day of the monthly bleeding, which was stopped in the hospital. Breast really hurt ceased 😂😂 (prescribed for fibrous mastopatitis), but bad things terrible. I read the reviews, they are just the opposite of the most often monthly disappear completely, less often turn into bleeding. Be careful with taking this drug!

I only drink indinol for 2 days, I was prescribed 2 tablets 2 times a day with a course of 3 months, the fact is that I now have monthly periods and they became abundant up to 2-3 pads per day. Does anyone have the same situation?

Indinol to drink during menstruation or stop for a time ms? Answer me. Pliz

Saw and drink Indole, but NSP-shny. There is no green tea and other things, only indole and broccoli inflorescence powder. For 4 months, polyps slowly left (the endometrium polyposis was the target). And the main reason for many years of trying to get pregnant (3 hister and a lot of hormones) psihanula and according to the purpose of the course Indole 2 tabl 3 times a day + Shakeshock 1 tab 3 times a day for 4 months received an excellent result (ultrasound I keep everything as a memory). I try to take Indola courses 2 times a year. But last year she missed the course in the second half of the year, and the result now is again an endometriotic cyst and a small polyp. I try again and again I hope for a good result.

And yes, with a cycle of problems there was no reception, saw during the months.

I have been drinking indinol forto for almost half a year. Mastopathy was gone, but with her and her period. Artificial menopause began. I experienced all his horror with ebbs and flows. Sensations from a burning stove in a snowdrift of snow. That wild heat, the wild cold! During the night I woke up to 7 times in a wet and sticky sweat, then right there from the cold, I couldn’t get a grudge against a tooth. And as a condition such that I did not want to live. Such thoughts went to my head, almost putting my hands on myself. looked swollen and scary. I suffered endlessly. Not yet thought to cancel. Menstruation gradually recovered, but went with delays of up to 40-60 days during the year, and then disappeared altogether. Ultrasound in the ovaries ended follicles. Now, the monthly will never come. I think that taking this drug, I approached menopause for several years.

I was prescribed a course of 3 months Indinol, after the first packing, the monthly began after 20 days and it has been pouring for 6 days already. Gynecologist prescribed hemostatic drugs. See what happens next (

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